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药物研究所

个人简介

于德泉,1932年生,籍贯山东蓬莱,天然药物化学家,中国工程院院士,药物研究所研究员,博士生导师。1952年考入北京医学院药学系药物化学专业,1956年获得学士学位。


主要研究方向

于德泉教授是我国著名的天然药物化学专家,中国工程院院士,从事天然药物化学研究工作60余年,完成了百余种中草药化学成分研究,首次发现过氧键为抗疟有效基团。参与主持了国家攻关项目“人工麝香”研究,该项目的投产创造了可观的经济效益,部分缓解了天然麝香紧缺问题,获国家科技进步一等奖(2015年)。系统地研究了三种藁本植物化学成分及其药理作用,发现四种具明显保肝和免疫抑制成分,完成全合成及构效关系研究。完成了秦艽、灵芝、连翘等常用中药化学成分基础研究,获得卫生部科技进步二等奖。在番荔枝科植物抗癌有效成分的研究中,发现70多种结构新颖的化合物,其中50多种具抗癌活性,该研究获卫生部科技进步二等奖。


代表性成果

黄金城赌城,澳门黄金城

图片

1. Bioactive bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandra, Renzhong Wang, Yanfei Liu, Guoru Shi, Jie Zhou, Jiayuan Li, Li, Li, Jiqiao Yuan, Xuyu Li,  Dequan Yu*, Bioorganic Chemistry, 2020, 98, 103697.

2. Iridal-Type Triterpenoids with a Cyclopentane Unit from the Rhizomes of Belamcanda chinensis, Jiayuan Li, Gang, Yanfei Liu, Zhenpeng Mai, Renzhong Wang, Dequan Yu*, J. Nat. Prod. 2019, 82, 1759-1767.

3. Nine new compounds form the whole plants of Rehmannia henryi, Jie Zhou, Guoru Shi, Yanfei Liu, Ruoyun Chen, Dequan Yu*, J. Asian Nat. Prod. Res. 2019, 21 (5) : 399-408.

4. Five new iridoids form the whole plants of Rehmannia henryi, Jie Zhou, Guoru Shi, Yanfei Liu, Ruoyun Chen, Dequan Yu*, J. Asian Nat. Prod. Res, 2019, 21 (8) : 727-734.

5. Heliojatrones A and B, two jatrophane-derived diterpenoids with a 5/10 fused-ring skeleton from Euphorbia helioscopia: structural elucidation and biomimetic conversion, Zhenpeng Mai, Gang Ni, Yanfei Liu, Li Li, Jiayuan Li, Dequan Yu*, Organic Letters, 2018, 20: 3124-3127.

6. Secoheliosphanes A and B and secoheliospholane A, three diterpenoids with unusual seco-jatrophane and seco-jatropholane skeletons from Euphorbia helioscopia, Zhenpeng Mai, Gang Ni, Yanfei Liu, Li Li, Jiayuan Li, Dequan Yu*, The Journal of Organic Chemistry 2018, 83 (1): 167-173.

7. Helioscopianoids A?Q, bioactive jatrophane diterpenoids esters from Euphorbia helioscopia, Zhenpeng Mai, Gang Ni, Yanfei Liu, Li Li, Naihong Chen, Dequan Yu*, Acta Pharmaceutica Sinica B, 2018, 8(5): 805-817.

8. Four new compounds from the rhizome of Aristolochia championii, Xin Wang, Guoru Shi, Yanfei Liu, Ruoyun Chen, Dequan Yu*, J. Asian Nat. Prod. Res, 2017, 19 (2): 114-120.

9. Polycycloiridals with a Cyclopentane Ring from Iris tectorum, Chunlei Zhang, Yanfei Liu, Yan Wang, Dong Liang, Zhibo Jiang, Li Li, Zhiyou Hao, Huan Luo, Guoru Shi, Ruoyun Chen, Zhengyu Cao, Dequan Yu*, J. Nat. Prod. 2017, 80, 156-161.

10. Polycycloiridals A?D, Four Iridal-Type Triterpenoids with an α-Terpineol Moiety from Iris tectorum, Chunlei Zhang, Zhiyou Hao, Yanfei Liu, Yan Wang, Guoru Shi, Zhibo Jiang, Ruoyun Chen, Zhengyu Cao, Dequan Yu*, Organic Letters, 2015, 17 5686-5689.