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生物医学工程研究所

个人简介

朱敦皖,1976年出生,籍贯安徽太湖,现任中国医学科学院生物医学工程研究所副所长、研究员、博士生导师。1994年考入四川大学化学纤维专业,1998年获得学士学位。2002年在天津大学材料学专业攻读硕士学位,从事生物材料研究。2005年在天津大学材料专业攻读博士学位,从事生物材料研究。2012年10月至2013年10月美国明尼苏达大学访问学者。2008年7月升为助理研究员,2011年9月为副研究员,2018年9月为研究员。


主要研究方向

针对肿瘤免疫治疗存在的脱靶副作用及有限的患者响应率等关键问题,重点开展新型纳米肿瘤疫苗、纳米生物材料介导肿瘤免疫联合治疗和生物材料与肿瘤免疫微环境等研究。


代表性成果

黄金城赌城,澳门黄金城

图片

1. Wang Nannan#, Zuo Yueyue#, Wu Shengjie, Huang Chenlu, Zhang Linhua*, and Zhu Dunwan*. Spatio-temporal delivery of both intra- and extracellular toll-like receptor agonists for enhancing antigen-specific immune responses. Acta Pharm Sin B. 2022;12(12):4486-4500. (IF=14.903)

2. Lu Yan, Gong Yonghua, Zhu Xianghui, Dong Xia*, Zhu Dunwan*, and Ma Guilei*. Design of Light-Activated Nanoplatform through Boosting "Eat Me" Signals for Improved CD47-Blocking Immunotherapy. Advanced Healthcare Materials. 2022, 11(10):e2102712. (IF=11.092)

3. Li Qianqian, Shi Zhaoqing, Zhang Fan, Zeng Weiwei, Zhu Dunwan*, and Mei Lin*. Symphony of nanomaterials and immunotherapy based on the cancer?immunity cycle. Acta Pharmaceutica Sinica B. 2022, 12(1):107-34. (IF=14.903)

4. Huang Chenlu, Zhang Li, Guo Qing, Zuo Yueyue, Wang Nannan, Wang Hai, Kong Deling*, Zhu Dunwan*, and Zhang Linhua*. Robust Nanovaccine Based on Polydopamine-Coated Mesoporous Silica Nanoparticles for Effective Photothermal-Immunotherapy Against Melanoma. Advanced Functional Materials. 2021, 31(18):2010637. (IF 18.808)

5. Zhang Zhiming#, Huang Chenlu#, Zhang Li, Guo Qing, Qin Yu, Fan Fan, Li Boxuan, Xiao Bao, Zhu Dunwan*, and Zhang Linhua*. pH-Sensitive and Bubble-Generating Mesoporous Silica-Based Nanoparticles for Enhanced Tumor Combination Therapy. Acta Pharmaceutica Sinica B. 2021, 11(2):520-33. (IF=11.614)

6. Zhang Linhua, Wu Shengjie, Qin Yu, Fan Fan, Zhang Zhiming, Huang Chenlu, Ji Weihang, Lu Lu, Wang Chun, Sun Hongfan, Leng Xigang, Kong Deling, and Zhu Dunwan*. Targeted Codelivery of an Antigen and Dual Agonists by Hybrid Nanoparticles for Enhanced Cancer Immunotherapy. Nano Letters. 2019, 19(7): 4237-49. (IF=11.238, 副封面论文)

7. Zhu Dunwan, Hu Chunyan, Fan Fan, Qin Yu, Huang Chenlu, Zhang Zhiming, Lu Lu, Wang Hai, Sun Hongfan, Leng Xigang, Wang Chun, Kong Deling, and Zhang Linhua*. Co-delivery of antigen and dual agonists by programmed mannose-targeted cationic lipid-hybrid polymersomes for enhanced vaccination. Biomaterials. 2019, 206:25-40. (IF=10.317)

8. Huang Chenlu#, Zhang Zhiming#, Guo Qin, Zhang Li, Fan Fan, Qin Yu, Wang Hai, Zhou Sheng, Ou-Yang Wenbin, Sun Hongfan, Leng Xigang, Pan Xiangbin, Kong Deling, Zhang Linhua*, and Zhu Dunwan*. A Dual-Model Imaging Theragnostic System Based on Mesoporous Silica Nanoparticles for Enhanced Cancer Phototherapy. Advanced Healthcare Materials. 2019, 8(19):e1900840. (IF=7.367)

9. Zhang Linhua#, Qin Yu#, Zhang Zhiming, Fan Fan, Huang Chenlu, Lu Li, Wang Hai, Jin Xu, Zhao Hanxue, Kong Deling, Wang Chun, Sun Hongfan, Leng Xigang, and Zhu Dunwan*. Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination. Acta Biomaterialia. 2018, 75:371-85. (IF=6.638)

10. Zhu Dunwan, Tao Wei, Zhang Hongling, Liu Gan, Wang Teng, Zhang Linhua, Zeng Xiaowei*, and Mei Lin*. Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer. Acta Biomaterialia. 2016, 30:144-54. (IF=6.319, C100)