贾美荣,1987年生,籍贯山东,中国医学科学院药物研究所研究员,博士生导师。2009年获得山东大学制药工程专业学士学位。2012年取得山东大学药物化学专业硕士学位,从事抗肿瘤药物研究。2016年取得美国Iowa State University生物化学专业博士学位,从事萜类生物合成研究。2016-2019年分别在美国Iowa State University和美国University of California, Davis进行博士后研究工作,主要进行萜类合成生物学研究。2021年作为助理教授到黄金城赌城,澳门黄金城:药物研究所工作。
本人致力于萜类等药用植物来源的活性天然物质的挖掘、生物合成、结构优化和异源生产,主要包括:基于整合组学的活性天然产物的功能基因元件挖掘和鉴定;结合计算模拟的生物酶催化机制阐明和功能设计改造;基于多元底盘的天然产物及中间体的高效异源生产和结构优化。
1. Muchlinski A#, Jia M#, Tiedge K#, Fell J, Pelot K, Chew L, Davisson D, Chen Y, Siegel J, Lovell J, and Zerbe P*. Cytochrome P450-catalyzed biosynthesis of furanoditerpenoids in the bioenergy crop switchgrass (Panicum virgatum L.). Plant J, 2021, 108: 1053–68 (IF = 6.417).
2. Jia M#, Zhang Y#, Siegel JB*, Tantillo DJ*, and Peters RJ*. Switching on a nontraditional enzymatic base–deprotonation by serine in the ent-kaurene synthase from Bradyrhizobium japonicum. ACS Catal. 2019, 9:8867-71 (IF = 11.406).
3. Jia M#, Mishra S, Tufts S, Jernigan R, and Peters RJ*. Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases. Metab Eng. 2019, 55:44-58 (IF = 7.875).
4. Jia M#, O’Brien TE, Zhang Y, Siegel JB, Tantillo DJ, and Peters RJ*. Changing face: A key residue for the addition of water by sclareol synthase. ACS Catal. 2018, 8:3133-7 (IF = 10.435).
5. Jia M#, Zhou K, Tufts S, Schulte S, and Peters RJ*. A pair of residues that interactively affect diterpene synthase product outcome. ACS Chem. Biol. 2017, 12(3):862-7 (IF = 5.139).
6. Jia M#, and Peters RJ*. Cis or Trans with class II diterpene cyclases. Org Biomol, 2017, 15:3158-60 (IF = 3.562).
7. Jia M#, Potter KC, and Peters RJ*. Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis. Metab Eng. 2016, 37:24-34 (IF = 7.742).
8. Jia M#, and Peters RJ*. Extending a single residue switch for abbreviating catalysis in plant ent-kaurene synthases. Front Plant Sci. 2016, 7:1765 (IF = 4.027).
9. Jia M#, Yang K, Fang H, Xu Y, Sun S, Su L, and Xu W*. Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine. Bioorg Med Chem. 2011, 19:5190-8 (IF = 2.958).